Over the last several years, Biosafety Cabinet (BSC) manufacturers have lowered downflow velocity while maintaining inflow velocity to increase energy efficiency, reduce exhaust system requirements and lower BSC Noise and vibration levels. However, the lowering of downflow velocity may come with a consequence of greater lateral airflow movement within the work zone creating more significant potential for cross-contamination. The lowering of the downflow velocity does not compromise personnel and product containment performance. Why? Primarily, by maintaining inflow velocity above a certain level as required by the standard, typically 100 fpm (.51 mps). However, the standard does not require a specific downflow velocity and can be adjusted as needed based on the design parameters of the work zone supply diffuser and grill patterns (airflow distribution) to assure compliance to the personnel and product protection requirements of NSF/ANSI 49. NSF/ANSI 49 test procedures do test for cross-contamination, but only at the work zone sidewalls, which doesn’t necessarily translate into the lateral movement of airflow in the center of the work zone. The result of these lower downflow velocities may be a higher level of sample cross-contamination using traditional work practice guidelines.
Home » Bulletins » [Bulletin] Impact of Class II Biosafety Cabinet Downflow Velocity on Cross Contamination
Most Recent Flipbooks
[Service Bulletin] Support and Product Replacement Policy
[Service Bulletin] CO2 Incubator Preventative Maintenance
[Service Bulletin] Ultralow Freezer Preventative Maintenance
[Bulletin] Care and Use of Copper Surfaces
NuAire lab products manufactured with copper such as CO2 Incubators have specific care and use instructions to assure maximum customer satisfaction.
[Bulletin] Horizontal Airflow Fixed (OSHPD) Seismic Anchorage Calculations/Installation
[Bulletin] Biosafety Cabinet Seismic Anchorage Calculations & Installation
[Bulletin] NU-959 UV Light Operation and Installation Instructions
[Bulletin] Single Stage CO2 Regulator NU-1590 Installation Instructions
[Bulletin] NU-C200V Bench Top Centrifuge Performance Evaluation
[Bulletin] Clarifying the Class II, Type C1 Biosafety Cabinet
The Class II, Type C1 Biosafety Cabinet (BSC) is similar to a Type B1 regarding airflow pattern. The Type C1 has a portion of the work surface to exhaust air.
[Bulletin] NuAire Laboratory Equipment Electrical Safety
This technical bulletin is intended review both UL and NFPA requirements and clarifies the requirements for non-patient care laboratyr and pharmacy equipment.
[Bulletin] Volatile Contaminant Air Concentrations in Type B Biosafety Cabinets
Use of volatiles in Class II, Type B Biosafety Cabinets (BSCs).
[Bulletin] Camera Usage in a Biosafety Cabinet and Pharmacy Isolator
NuAire offers general guidance to aid in the selection of camera systems that can be mounted on or near your primary engineering controls.
[Bulletin] NU-S125 Performance Evaluation
[Bulletin] NU-480 Decontamination by Vaporized Hydrogen Peroxide
[Bulletin] NU-480-600E Decontamination Process Testing Results
[Bulletin] Concurrent Balance Value of Class II, Type B1/B2 Biosafety Cabinets
The field certification of Biosafety Cabinets (BSC’s) as required in Annex F of the NSF/ANSI 49 class II biosafety cabinetry standard is based on the principle of replication.
[Bulletin] Movement and Re-Certification of a Biosafety Cabinet
[Bulletin] NU-NTE797 Main Chamber Pressure Specification Change
NU-NTE800 Performance Evaluation Compliance to USP 797 / USP 800