As guidelines for cleanrooms continue to evolve, enforcement of these safety guidelines has also increased. Within health systems and hospitals, sterile cleanrooms are a primary focus of regulators' reviews. During a 2019 Joint Commission visit, one of the four primary areas of focus throughout the hospital was sterile cleanrooms. This means that pharmacy represented 25% of the overall survey concentration. In order to ensure the standards are being met, it is important for pharmacy leaders to conduct internal mock surveys, maintain appropriate documentation, and address the importance of compliance standards in their cleanrooms.