Video

Airflow in a Negative Pressure Compounding Aseptic Containment Isolator

The airflow pattern in a negative pressure compounding aseptic containment isolator (CACI) is designed to maintain a negative pressure inside the isolator relative to the surrounding area. A CACI creates a HEPA-filtered unidirectional supply airflow at 20 air changes per minute within the work zone and interchange areas to assure ISO Class 5 conditions. Utilizing unidirectional airflow ensures a continuous stream of HEPA-filtered air across the work zone and interchange areas assuring sterility and minimizing cross-contamination. Once the air is through the work area, the airflow is split from front to rear. Then proceeds under the work tray up the rear divider panel and is exhausted through the exhaust HEPA filter housing that is connected to the facility's exhaust system. The Interchange area is maintained at slightly more negative pressure than the work zone to maintain product sterility.